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This page was last changed on 11 April 2017, at 16:14. Enter the terms you wish to search for. Venkataraman, works on developing next generation materials for energy conversion and storage. Gierasch Winner of the Ralph F. Gierasch was awarded the Ralph F. Hirschmann Award in Peptide Chemistry for her seminal contributions to peptide structure and function, peptide models for protein folding and function, and roles of peptide and protein aggregation in disease.
The environment in a cell is extremely complex and challenging for the process of protein folding, leading to a need for a network of species that protect protein states that are susceptible to aggregation—the protein homeostasis network. We are working with colleagues and collaborators to understand the underlying mechanisms of protein homeostasis from the level of the molecular chaperone machines that act on protein clients to the coordinated action of the network in all of its complexity. We would love to witness and contribute to new discoveries related to these questions, both because of the fascinating basic science involved and because failures in these systems are implicated in a wide array of diseases, including neurodegenerative diseases. 615,000 NIH grant entitled, “Assembly and Function of Bacterial Chemotaxis Receptor Signaling Complexes. The goal of this project is to assemble native-like functional nanoarrays of chemotaxis receptor complexes and determine how the proteins change their structure and dynamics during signaling. Understanding signaling in this system may be useful for the development of novel antibiotics targeting similar signaling systems that are widespread in bacteria.